Squamous cell carcinoma: Squamous cell carcinoma (SCC) is the second most common cancer of the skin. Squamous cell carcinoma arises in the outer layer of the skin (the epithelium). Middle-aged and elderly persons, especially those with fair complexions and frequent sun exposure, are most likely to develop SCC.. Squamous cell carcinomas often arise from small sandpaper-like growths called solar or actinic keratoses. It is rare for SCC to spread to local lymph nodes and internal organs, but metastasis can happen when high-risk SCC is not promptly diagnosed and treated. Squamous Cell cancers are curable, and are treated with surgical procedures (excision, electrodessication and curettage, Mohs Micrographic Surgery), Photodynamic therapy or Imiquimod cream, depending on the type of cancer, its location and its size.