Hyperpigmentation is darkening of the skin or nails that may be caused by sun damage, inflammation (such as acne), systemic diseases, hormonal causes (also called melasma) and skin injuries. Various treatments are available for hyperpigmentation. Topical products that contain hydroquinone, tretinoin, steroids and alpha hydroxy acids are very effective for hyperpigmentation if they are combined with aggressive sun protection behavior. Sun protection with sunscreens (SPF 30 or above) AND protective clothing and hats is the most important aspect of hyperpigmentation therapy and prevention. Some good prescription products for hyperpigmentation and melasma are Eldoquin, Epiquin Micro, Glyquin, Lustra, Melanex and Tri-Luma. Certain laser and light treatments are also effective for hyperpigmentation.